Solak Berna, Metin Nurcan, Erdem Mustafa Teoman
Department of Dermatology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Am J Ther. 2016 Jul-Aug;23(4):e1116-7. doi: 10.1097/MJT.0000000000000081.
Acitretin is a synthetic oral retinoid that has been used for a number of dermatological diseases. Several side effects of acitretin have been reported such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity. Many drugs, mainly antibiotics and nonsteroidal anti-inflammatory drugs, can cause angioedema-urticaria. We present the case of angioedema-urticaria due to acitretin, confirmed by oral provocation test, in a 61-year-old man with psoriasis. To the best of our knowledge, only 1 case of angioedema due to oral acitretin has been reported in the literature so far. We report this case to draw attention that acitretin may cause angioedema-urticaria and to inform patients about this risk besides other side effects due to acitretin.
阿维A是一种合成的口服类视黄醇，已被用于多种皮肤病的治疗。阿维A的一些副作用已被报道，如致畸性、唇炎、皮肤干燥、血脂异常和光敏性。许多药物，主要是抗生素和非甾体抗炎药，可引起血管性水肿-荨麻疹。我们报告一例61岁银屑病男性患者，经口服激发试验证实，因阿维A导致血管性水肿-荨麻疹。据我们所知，迄今为止文献中仅报道过1例口服阿维A引起血管性水肿的病例。我们报告此病例是为了引起人们对阿维A可能导致血管性水肿-荨麻疹的关注，并告知患者除阿维A的其他副作用外，还存在这种风险。
