阿维A——一种用于治疗银屑病的系统性类维生素A药物的最新综述。
An updated review of acitretin--a systemic retinoid for the treatment of psoriasis.
作者信息
Pang Mei-Lin, Murase Jenny E, Koo John
机构信息
University of California, San Francisco, Department of Dermatology, San Francisco, CA, USA.
出版信息
Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):953-64. doi: 10.1517/17425255.4.7.953.
BACKGROUND
Acitretin is a systemic retinoid used for psoriasis. It normalizes cellular differentiation and maturation and is also used as a chemopreventive agent against cutaneous malignancies. However, it is not used frequently because of its side-effect profile.
OBJECTIVE
Safety and efficacy of acitretin was evaluated as monotherapy, as well as in combination with other systemic agents.
METHODS
Medical literature from 2005 to 2008 was reviewed. The most scientifically rigorous clinical trials were selected for Psoriasis Area and Severity Index. Articles were limited to case reports or clinical trials, human subjects and English language journals.
RESULTS/CONCLUSION: Acitretin is effective as monotherapy for pustular and erythrodermic psoriasis and for plaque psoriasis (with other systemic agents). Side effects of acitretin use occur more commonly with high doses. Hence, acitretin is safe and effective for psoriasis.
背景
阿维A是一种用于治疗银屑病的系统性维甲酸类药物。它可使细胞分化和成熟正常化，也用作预防皮肤恶性肿瘤的化学预防剂。然而，由于其副作用，它并不经常使用。
目的
评估阿维A作为单一疗法以及与其他系统性药物联合使用时的安全性和有效性。
方法
回顾了2005年至2008年的医学文献。为银屑病面积和严重程度指数选择了最具科学严谨性的临床试验。文章限于病例报告或临床试验、人类受试者和英文期刊。
结果/结论：阿维A作为单一疗法对脓疱型和红皮病型银屑病以及斑块状银屑病（与其他系统性药物联合使用时）有效。高剂量使用阿维A时副作用更常见。因此，阿维A对银屑病安全有效。
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