Shao Min, Wu Yunjun, Feng Zhijun, Gu Xiaoxia, Wang Shaoyin
Department of Chemistry, Wannan Medical College, Wuhu, Anhui 241002, China.
Org Biomol Chem. 2016 Feb 28;14(8):2515-21. doi: 10.1039/c5ob02658j.
An efficient, environmentally friendly and high-yielding route from inexpensive starting materials to 1,2-dihydroquinolines has been developed. This procedure proceeded via a cascade Friedel-Crafts-type reaction and 6-endo-trig hydroamination under the catalysis of FeCl3·6H2O, involving the formation of two new σ (C-C and C-N) bonds in a single operation for the construction of a 1,2-dihydroquinoline skeleton in good to excellent yields.
已经开发出一种从廉价起始原料到1,2 - 二氢喹啉的高效、环境友好且高产率的路线。该方法在FeCl3·6H2O催化下通过级联傅克型反应和6-内型-三环氢胺化反应进行，在单一操作中涉及形成两个新的σ（C - C和C - N）键，以良好至优异的产率构建1,2 - 二氢喹啉骨架。
