一种通用且高效的三氯化铁催化的炔丙醇亲核取代反应。
A general and efficient FeCl3-catalyzed nucleophilic substitution of propargylic alcohols.
作者信息
Zhan Zhuang-ping, Yu Jing-liang, Liu Hui-juan, Cui Yuan-yuan, Yang Rui-feng, Yang Wen-zhen, Li Jun-ping
机构信息
Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.
出版信息
J Org Chem. 2006 Oct 13;71(21):8298-301. doi: 10.1021/jo061234p.
PMID:17025331
Abstract
A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, leading to the construction of C-C, C-O, C-S and C-N bonds, has been developed.
摘要
已开发出一种通用且高效的三氯化铁催化的炔丙醇与以碳和杂原子为中心的亲核试剂（如烯丙基三甲基硅烷、醇、芳香化合物、硫醇和酰胺）的取代反应，该反应可构建碳-碳、碳-氧、碳-硫和碳-氮键。
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