Rosenthal Susan L, de Roche Ariel M, Catallozzi Marina, Breitkopf Carmen Radecki, Ipp Lisa S, Chang Jane, Francis Jenny K R, Hu Mei-Chen
Department of Pediatrics, Columbia University Medical Center - College of Physicians and Surgeons, New York, New York; Department of Psychiatry, Columbia University Medical Center - College of Physicians and Surgeons, New York, New York; New York-Presbyterian Hospital, New York, New York.
Department of Pediatrics, Columbia University Medical Center - College of Physicians and Surgeons, New York, New York.
J Pediatr Adolesc Gynecol. 2016 Aug;29(4):372-7. doi: 10.1016/j.jpag.2016.01.119. Epub 2016 Jan 25.
To understand parent and adolescent attitudes toward parental involvement during clinical trials and factors related to those attitudes.
As part of a study on willingness to participate in a hypothetical microbicide study, adolescents and their parents were interviewed separately.
Adolescent medicine clinics in New York City.
There were 301 dyads of adolescents (ages 14-17 years; 62% female; 72% Hispanic) and their parents.
None.
The interview included questions on demographic characteristics, sexual history, and family environment (subscales of the Family Environment Scale) that were associated with attitudes about parental involvement.
Factor analysis of the parental involvement scale yielded 2 factors: LEARN, reflecting gaining knowledge about study test results and behaviors (4 items) and PROCEDURE, reflecting enrollment and permissions (4 items). Adolescents endorsed significantly fewer items on the LEARN scale and the PROCEDURE scale indicating that adolescents believed in less parental involvement. There was no significant concordance between adolescents and their own parents on the LEARN scale and the PROCEDURE scale. In final multivariate models predicting attitudes, adolescents who were female and had sexual contact beyond kissing, and non-Hispanic parents had lower LEARN scores. Adolescents who were older, had previous research experience, and reported less moral or religious emphasis in their family had lower PROCEDURE scores; there were no significant predictors for parents in the multivariate analyses.
Parents wanted greater involvement in the research process than adolescents. Recruitment and retention might be enhanced by managing these differing expectations.
了解父母与青少年对临床试验中父母参与的态度以及与这些态度相关的因素。
作为一项关于参与假设性杀微生物剂研究意愿的研究的一部分，青少年及其父母分别接受了访谈。
纽约市的青少年医学诊所。
301对青少年（年龄在14 - 17岁；62%为女性；72%为西班牙裔）及其父母。
无。
访谈包括有关人口统计学特征、性史和家庭环境（家庭环境量表的子量表）的问题，这些与对父母参与的态度相关。
对父母参与量表进行因子分析得出2个因子：学习，反映获取关于研究测试结果和行为的知识（4个项目）以及程序，反映登记和许可（4个项目）。青少年在学习量表和程序量表上认可的项目明显较少，这表明青少年认为父母参与较少。在学习量表和程序量表上，青少年与其父母之间没有显著的一致性。在预测态度的最终多变量模型中，女性且有除亲吻之外性接触的青少年以及非西班牙裔父母的学习得分较低。年龄较大、有过研究经历且报告家庭中道德或宗教强调较少的青少年的程序得分较低；在多变量分析中，没有父母的显著预测因素。
父母比青少年希望在研究过程中有更多参与。通过处理这些不同的期望，可能会提高招募和留存率。
