Lee Y H, Bae S-C
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, 136-705, Seoul, Korea.
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Z Rheumatol. 2016 Dec;75(10):1021-1027. doi: 10.1007/s00393-016-0050-1.
This study aimed to evaluate the relationship between the circulating serum leptin level and rheumatoid arthritis (RA) and to establish a correlation between serum leptin levels and RA activity.
We searched the PUBMED, EMBASE, and Cochrane databases. A meta-analysis was performed, comparing the serum/plasma leptin levels in patients with RA and healthy controls. Correlation coefficients between serum leptin level and either disease activity score 28 (DAS28) or C‑reactive protein (CRP) in RA patients were also examined.
Thirteen studies with a total of 648 RA patients and 426 controls were included in this meta-analysis. Circulating leptin level was significantly higher in the RA group than in the control group (SMD = 1.056, 95 % CI = 0.647-1.465, p = 4.2 × 10). In addition, stratification by ethnicity showed a significantly elevated leptin level in the RA group in Caucasian, Turkish, and Arab populations (SMD = 0.813, 95 % CI = 0.137-1.490, p = 0.018, SMD = 0.981, 95 % CI = 0.307-1.655, p = 0.004, and SMD = 1.469, 95 % CI = 0.443-2.495, p = 0.005 respectively). A meta-analysis of correlation coefficients showed a small but significantly positive correlation between the circulating leptin level and either DAS28 (correlation coefficient = 0.275, 95 % CI = 0.076-0.452, p = 0.007) or CRP (correlation coefficient = 0.274, 95 % CI = 0.068-0.458, p = 0.010).
Our meta-analysis demonstrated that the circulating leptin level is significantly higher in patients with RA and that a small but significantly positive correlation exists between leptin levels and RA activity.
本研究旨在评估循环血清瘦素水平与类风湿关节炎（RA）之间的关系，并建立血清瘦素水平与RA活动度之间的相关性。
我们检索了PUBMED、EMBASE和Cochrane数据库。进行了一项荟萃分析，比较RA患者和健康对照者的血清/血浆瘦素水平。还检测了RA患者血清瘦素水平与疾病活动评分28（DAS28）或C反应蛋白（CRP）之间的相关系数。
本荟萃分析纳入了13项研究，共648例RA患者和426例对照者。RA组的循环瘦素水平显著高于对照组（标准化均数差=1.056，95%置信区间=0.647-1.465，p=4.2×10）。此外，按种族分层显示，在白种人、土耳其人和阿拉伯人群的RA组中，瘦素水平显著升高（标准化均数差分别为=0.813，95%置信区间=0.137-1.490，p=0.018；标准化均数差=0.981，95%置信区间=0.307-1.655，p=0.004；标准化均数差=1.469，95%置信区间=0.443-2.495，p=0.005）。相关系数的荟萃分析显示，循环瘦素水平与DAS28（相关系数=0.275，95%置信区间=0.076-0.452，p=0.007）或CRP（相关系数=0.274，95%置信区间=0.068-0.458，p=0.010）之间存在小但显著的正相关。
我们的荟萃分析表明，RA患者的循环瘦素水平显著更高，且瘦素水平与RA活动度之间存在小但显著的正相关。
