Bae Sang-Cheol, Lee Young Ho
a Department of Rheumatology , Hanyang University Hospital for Rheumatic Diseases , Seoul , Korea.
b Division of Rheumatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Korea.
Postgrad Med. 2017 Jun;129(5):531-537. doi: 10.1080/00325481.2017.1319729. Epub 2017 Apr 24.
We evaluated the relationship between calprotectin levels and rheumatoid arthritis (RA), and the correlation between plasma/serum calprotectin and RA activity.
We searched PUBMED, EMBASE, and Cochrane databases and performed meta-analyses comparing plasma/serum or synovial fluid calprotectin levels in RA patients and controls, and correlation coefficients between calprotectin levels and disease activity for 28 joints (DAS28) as well as C-reactive protein (CRP) in RA patients.
Sixteen studies including 849 RA patients and 266 controls were available for meta-analysis. Meta-analysis showed that calprotectin levels were significantly higher in the RA group than in the control group (SMD = 2.337, 95% CI = 1.544-3.130, p < 1.0 × 10). Stratification by rheumatoid factor (RF) status revealed significantly elevated calprotectin levels in the RF-positive RA group compared to that of the RF-negative RA group (SMD = 0.574, 95% CI = 0.345-0.804, p = 9.2 × 10). Meta-analysis of correlation coefficients identified a significant positive correlation between calprotectin levels and CRP or DAS28 (correlation coefficient for CRP = 0.566, 95% CI = 0.512-0.615, p < 1.0 × 10; correlation coefficient for DAS28 = 0.438, 95% CI = 0.269-0.518, p = 2.5 × 10). Calprotectin levels in synovial fluid were significantly higher in the RA group than in the control group (SMD = 2.891, 95% CI = 1.067-4.715, p = 0.002).
Our meta-analysis demonstrates that circulating and synovial fluid calprotectin levels are high in patients with RA, and that circulating calprotectin levels positively correlate with RA activity.
我们评估了钙卫蛋白水平与类风湿关节炎（RA）之间的关系，以及血浆/血清钙卫蛋白与RA活动度之间的相关性。
我们检索了PUBMED、EMBASE和Cochrane数据库，并进行了荟萃分析，比较RA患者和对照组的血浆/血清或滑液钙卫蛋白水平，以及RA患者中钙卫蛋白水平与28个关节疾病活动度（DAS28）和C反应蛋白（CRP）之间的相关系数。
16项研究（包括849例RA患者和266例对照）可用于荟萃分析。荟萃分析显示，RA组的钙卫蛋白水平显著高于对照组（标准化均数差[SMD]=2.337，95%可信区间[CI]=1.544 - 3.130，p<1.0×10）。按类风湿因子（RF）状态分层显示，RF阳性RA组的钙卫蛋白水平显著高于RF阴性RA组（SMD=0.574，95%CI=0.345 - 0.804，p=9.2×10）。相关系数的荟萃分析确定钙卫蛋白水平与CRP或DAS28之间存在显著正相关（CRP的相关系数=0.566，95%CI=0.512 - 0.615，p<1.0×10；DAS28的相关系数=0.438，95%CI=0.269 - 0.518，p=2.5×10）。RA组滑液中的钙卫蛋白水平显著高于对照组（SMD=2.891，95%CI=1.067 - 4.715，p=0.002）。
我们的荟萃分析表明，RA患者的循环和滑液钙卫蛋白水平较高，且循环钙卫蛋白水平与RA活动度呈正相关。
