通过荧光原位杂交（FISH）评估人乳腺癌福尔马林固定石蜡包埋（FFPE）组织标本中的人表皮生长因子受体2（HER2）基因状态。
Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).
作者信息
Hwang Harry C, Gown Allen M
机构信息
Department of Molecular Pathology, PhenoPath Laboratories, 551 North 34th Street, Seattle, WA, 98103-8675, USA.
出版信息
Methods Mol Biol. 2016;1406:61-70. doi: 10.1007/978-1-4939-3444-7_5.
Current standard of care requires that HER2 gene testing be performed on all newly diagnosed invasive breast cancers in order to determine eligibility for anti-HER2 antibody therapy and should be performed in accordance with current ASCO-CAP guidelines (Hammond et al., J Clin Oncol 29(15):e458, 2011; Wolff et al., J Clin Oncol 31(31):3997-4013, 2013). Here we describe a HER2 FISH methodology to evaluate HER2 gene status in FFPE breast tumor specimens.
当前的护理标准要求对所有新诊断的浸润性乳腺癌进行HER2基因检测，以确定是否适合接受抗HER2抗体治疗，并且应按照当前的美国临床肿瘤学会（ASCO）-美国病理学家学会（CAP）指南进行检测（Hammond等人，《临床肿瘤学杂志》29(15):e458，2011年；Wolff等人，《临床肿瘤学杂志》31(31):3997 - 4013，2013年）。在此，我们描述一种HER2荧光原位杂交（FISH）方法，用于评估福尔马林固定石蜡包埋（FFPE）乳腺肿瘤标本中的HER2基因状态。
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