Frey Melissa K, David-West Gizelka, Mittal Khushbakhat R, Muggia Franco M, Pothuri Bhavana
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New York University Langone Medical Center, New York, NY 10016, USA.
Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA.
Ecancermedicalscience. 2016 Jan 18;10:613. doi: 10.3332/ecancer.2016.613. eCollection 2016.
Occult endometrial cancer is occasionally discovered in women with Lynch syndrome undergoing risk-reducing hysterectomy. The case presented here demonstrates that preoperative endometrial sampling can help detect these occult cancers; however, there are currently no recommendations for this preoperative intervention. A 50-year-old woman with Lynch syndrome underwent endometrial sampling prior to planned risk-reducing hysterectomy and bilateral salpingo-oophorectomy. The endometrial biopsy demonstrated a serous endometrial cancer. The patient was counselled regarding the diagnosis and revised operative plan, which now included staging, prior to surgery. Although the prevalence of occult endometrial cancer at the time of risk-reducing surgery in women with Lynch syndrome remains unknown, preoperative endometrial sampling may allow for improved patient counselling and surgical planning in this population, and can help avoid a subsequent surgery for staging.
隐匿性子宫内膜癌偶尔会在因林奇综合征而接受降低风险子宫切除术的女性中被发现。本文介绍的病例表明，术前子宫内膜取样有助于检测这些隐匿性癌症；然而，目前对于这种术前干预尚无推荐意见。一名50岁的林奇综合征女性在计划进行降低风险子宫切除术及双侧输卵管卵巢切除术之前接受了子宫内膜取样。子宫内膜活检显示为浆液性子宫内膜癌。在手术前，就该诊断及修订后的手术计划（现包括分期）向患者提供了咨询。尽管林奇综合征女性在进行降低风险手术时隐匿性子宫内膜癌的患病率仍不清楚，但术前子宫内膜取样可能有助于改善该人群患者的咨询及手术规划，并有助于避免后续的分期手术。
