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Diverse proportion in composite pheochromocytoma-ganglioneuroma may induce varied clinical symptom: comparison of two cases.复合性嗜铬细胞瘤-神经节神经瘤中不同比例可能导致不同的临床症状:两例病例比较。
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15369-74. eCollection 2015.
2
Divergent differentiation in neuroendocrine tumors of the adrenal gland.肾上腺神经内分泌肿瘤中的分化差异
Semin Diagn Pathol. 2000 May;17(2):120-6.
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Bilateral pheochromocytoma-ganglioneuroma of the adrenal in type 1 neurofibromatosis.1型神经纤维瘤病中的双侧肾上腺嗜铬细胞瘤-神经节神经瘤
Am J Surg Pathol. 1993 Aug;17(8):837-41. doi: 10.1097/00000478-199308000-00009.
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Composite pheochromocytoma of the adrenal gland: a case series.肾上腺复合性嗜铬细胞瘤:病例系列
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Functional 'composite' pheochromocytoma-ganglioneuroma presenting as a pancreatic mass.功能性“复合”嗜铬细胞瘤-节细胞神经瘤表现为胰腺肿块。
Pancreatology. 2012 May-Jun;12(3):211-4. doi: 10.1016/j.pan.2012.02.001. Epub 2012 Feb 8.
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Mixed cortical adenoma and composite pheochromocytoma-ganglioneuroma: an unusual corticomedullary tumor of the adrenal gland.混合性皮质腺瘤和复合嗜铬细胞瘤-神经节细胞瘤:一种不常见的肾上腺皮质-髓质肿瘤。
Ann Diagn Pathol. 2011 Jun;15(3):185-9. doi: 10.1016/j.anndiagpath.2010.02.005. Epub 2010 Apr 29.
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Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases.肾上腺及肾上腺外无功能复合性嗜铬细胞瘤/副神经节瘤伴免疫组化异位激素表达:两例病例比较
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[Composite pheochromocytoma with ganglioneuroma in the adrenal gland: a case report].[肾上腺复合型嗜铬细胞瘤合并神经节瘤:一例报告]
Hinyokika Kiyo. 1998 Aug;44(8):575-7.
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[Watery diarrhea, hypokalemia, achlorhydria syndrome due to recurrent malignant pheochromocytoma].复发性恶性嗜铬细胞瘤所致水样腹泻、低钾血症、无胃酸综合征
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Composite adrenal phaeochromocytoma-ganglioneuroma causing watery diarrhoea, hypokalaemia and achlorhydria syndrome.复合性肾上腺嗜铬细胞瘤-神经节瘤导致水样腹泻、低钾血症和低胃酸分泌综合征。
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Case Report: Composite pheochromocytoma with ganglioneuroma component: A report of three cases.病例报告:复合性嗜铬细胞瘤伴神经节细胞瘤成分:三例报告。
Front Endocrinol (Lausanne). 2022 Sep 14;13:903085. doi: 10.3389/fendo.2022.903085. eCollection 2022.
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Composite phaeochromocytomas-a systematic review of published literature.复合嗜铬细胞瘤——文献系统综述。
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A Novel MAX Gene Mutation Variant in a Patient With Multiple and "Composite" Neuroendocrine-Neuroblastic Tumors.一例伴有多发性“复合性”神经内分泌-神经母细胞瘤的新型 MAX 基因突变变异体。
Front Endocrinol (Lausanne). 2020 May 19;11:234. doi: 10.3389/fendo.2020.00234. eCollection 2020.

本文引用的文献

1
Retroperitoneal composite pheochromocytoma-ganglioneuroma : a case report and review of literature.腹膜后复合嗜铬细胞瘤-神经节细胞瘤:病例报告及文献复习。
Diagn Pathol. 2013 Apr 15;8:63. doi: 10.1186/1746-1596-8-63.
2
Pheochromocytoma with histologic transformation to composite type, complicated by watery diarrhea, hypokalemia, and achlorhydria syndrome.组织学转化为混合型的嗜铬细胞瘤,并发水样腹泻、低钾血症和胃酸缺乏综合征。
Endocr Pract. 2012 Jul-Aug;18(4):e91-6. doi: 10.4158/EP11370.CR.
3
Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases.肾上腺及肾上腺外无功能复合性嗜铬细胞瘤/副神经节瘤伴免疫组化异位激素表达:两例病例比较
Urol Int. 2010;85(3):368-72. doi: 10.1159/000317312. Epub 2010 Sep 9.
4
Composite pheochromocytoma-ganglioneuroma: a rare experiment of nature.复合嗜铬细胞瘤-节细胞神经瘤:大自然的罕见实验。
Endocr Pract. 2010 Mar-Apr;16(2):291-9. doi: 10.4158/EP09205.RA.
5
Composite malignant pheochromocytoma with malignant peripheral nerve sheath tumour: a case with 28 years of tumour-bearing history.复合性恶性嗜铬细胞瘤合并恶性外周神经鞘瘤:一例有28年肿瘤病史的病例
Histopathology. 2007 Sep;51(3):420-2. doi: 10.1111/j.1365-2559.2007.02781.x.
6
Pheochromocytoma and paraganglioma in children: a review of medical and surgical management at a tertiary care center.儿童嗜铬细胞瘤和副神经节瘤:三级医疗中心的医学与外科治疗综述
Pediatrics. 2006 Sep;118(3):1109-17. doi: 10.1542/peds.2005-2299.
7
Composite Paraganglioma-Ganglioneuroma of the Urinary Bladder: A Clinicopathologic, Immunohistochemical, and UItrastructural Study of a Case and Review of the Literature.膀胱副神经节瘤-神经节神经瘤复合体:1例临床病理、免疫组织化学及超微结构研究并文献复习
Endocr Pathol. 1998 Winter;9(1):353-361.
8
Composite Pheochromocytoma-Ganglioneuroma of the Adrenal Gland: An Uncommon Entity with Distinctive Clinicopathologic Features.肾上腺复合性嗜铬细胞瘤-神经节瘤:一种具有独特临床病理特征的罕见实体瘤。
Endocr Pathol. 1999 Winter;10(4):343-352. doi: 10.1007/BF02739777.
9
Pheochromocytoma associated with neuroendocrine carcinoma. A new type of composite pheochromocytoma.嗜铬细胞瘤伴神经内分泌癌。一种新型复合性嗜铬细胞瘤。
Arch Pathol Lab Med. 1999 Dec;123(12):1274-9. doi: 10.5858/1999-123-1274-PAWNC.
10
Composite phaeochromocytoma-ganglioneuroblastoma in a patient with multiple endocrine neoplasia type IIA.一名患有IIA型多发性内分泌腺瘤病的患者出现复合性嗜铬细胞瘤-神经母细胞瘤。
Histopathology. 1998 Mar;32(3):281-2. doi: 10.1046/j.1365-2559.1998.0372g.x.

复合性嗜铬细胞瘤-神经节神经瘤中不同比例可能导致不同的临床症状:两例病例比较。

Diverse proportion in composite pheochromocytoma-ganglioneuroma may induce varied clinical symptom: comparison of two cases.

作者信息

Zhang Bu-Yi, Zhao Mingfei, Li Baizhou, Zhang Jian-Min

机构信息

Department of Pathology, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.

Department of Neurosurgery, School of Medicine, Second Affiliated Hospital of Zhejiang University Hangzhou, PR China.

出版信息

Int J Clin Exp Pathol. 2015 Nov 1;8(11):15369-74. eCollection 2015.

PMID:26823896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4713682/
Abstract

Composite pheochromocytoma-ganglioneuroma is extremely rare. We described two cases of composite pheochromocytomas in the adrenal medullar. Case 1 was a 70-year-old male presenting with lower abdominal pain and normal blood electrolytes. Case 2 was a 48-year-old female with palpitation and back tenderness. Biochemical investigations showed hypocalcium, hypokalemia and high level of vma. The histological images and the immunohistochemical staining demonstrated the two cases composed of pheochromocytoma and ganglioneuromoma components. Ganglioneuroma component in case 2 accounted for more proportion than that in case 1. We speculated that the varied clinical symptoms were related with the diverse proportions in composite pheochromocytome-ganglioneuroma.

摘要

嗜铬细胞瘤-神经节神经瘤复合体极为罕见。我们描述了两例肾上腺髓质的嗜铬细胞瘤-神经节神经瘤复合体病例。病例1是一名70岁男性,表现为下腹部疼痛且血液电解质正常。病例2是一名48岁女性,有心悸和背部压痛。生化检查显示低钙血症、低钾血症和高香草酸水平升高。组织学图像和免疫组化染色表明这两例病例由嗜铬细胞瘤和神经节神经瘤成分组成。病例2中的神经节神经瘤成分占比高于病例1。我们推测不同的临床症状与嗜铬细胞瘤-神经节神经瘤复合体中不同的占比有关。