Ebert T, Platz M, Kralisch S, Lossner U, Jessnitzer B, Richter J, Blüher M, Stumvoll M, Fasshauer M
Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Exp Clin Endocrinol Diabetes. 2016 Apr;124(4):257-60. doi: 10.1055/s-0035-1565172. Epub 2016 Jan 29.
Copeptin, the c-terminal part of pro-Arginine vasopressin, has recently been introduced as a novel risk factor to develop facets of the metabolic syndrome. However, regulation of copeptin in pregnancy-associated metabolic disease, i. e., gestational diabetes mellitus (GDM), has not been fully understood, so far.
For this study, 74 GDM patients and 74 healthy, pregnant, age-, body mass index-, and gestational age-matched controls were recruited. Serum levels of copeptin were quantified by an illuminometric assay. Furthermore, copeptin concentrations were correlated to biochemical and anthropometric markers of obesity, glucose and lipid metabolism, renal function, and inflammation.
Median [interquartile range] serum copeptin levels were significantly lower in subjects with GDM (3.5 [2.0] pmol/l) as compared to controls (4.4 [3.2] pmol/l) (p<0.05). Furthermore, GDM remained an independent predictor of circulating copeptin in multivariate regression analysis (p<0.05). Moreover, copeptin was independently associated with gestational age at blood sampling (p<0.05).
Copeptin serum levels are significantly lower in GDM as compared to healthy pregnant controls. Further studies are needed to better clarify the pathophysiological role of copeptin in GDM.
copeptin，即精氨酸加压素原的c末端部分，最近被引入作为代谢综合征各方面发展的一种新的风险因素。然而，迄今为止，copeptin在妊娠相关代谢疾病，即妊娠期糖尿病（GDM）中的调节尚未完全明确。
在本研究中，招募了74例GDM患者和74例健康、怀孕、年龄、体重指数和孕周匹配的对照者。通过发光测定法定量copeptin的血清水平。此外，将copeptin浓度与肥胖、葡萄糖和脂质代谢、肾功能及炎症的生化和人体测量学标志物进行相关性分析。
GDM患者的copeptin血清水平中位数[四分位间距]（3.5 [2.0] pmol/l）显著低于对照组（4.4 [3.2] pmol/l）（p<0.05）。此外，在多变量回归分析中，GDM仍然是循环copeptin的独立预测因素（p<0.05）。而且，copeptin与采血时的孕周独立相关（p<0.05）。
与健康孕妇对照组相比，GDM患者的copeptin血清水平显著降低。需要进一步研究以更好地阐明copeptin在GDM中的病理生理作用。
