Ebert Thomas, Stepan Holger, Schrey Susanne, Kralisch Susan, Hindricks Janka, Hopf Lisa, Platz Martin, Lossner Ulrike, Jessnitzer Beate, Drewlo Sascha, Blüher Matthias, Stumvoll Michael, Fasshauer Mathias
University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
Cytokine. 2014 Feb;65(2):153-8. doi: 10.1016/j.cyto.2013.11.009. Epub 2013 Dec 16.
Irisin has recently been introduced as a novel an exercise-inducible myokine which improves glucose metabolism in mice. However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far.
Circulating irisin was quantified in 74 GDM patients and in 74 healthy, pregnant, gestational age-matched controls. In a subset of these patients (44 GDM, 41 controls), postpartum follow-up data were also available. In a second study population of 40 healthy women with singleton pregnancies undergoing elective Cesarean section, irisin was assessed in maternal serum before and within 24h after delivery, as well as in umbilical cord blood and in placental tissue.
In the first study population, median [interquartile range] irisin levels were significantly higher in GDM patients as compared to controls after delivery (previous GDM: 446.3 [146.9]μg/l; controls: 378.0 [111.4]μg/l) but not during pregnancy (GDM: 482.1 [132.1]μg/l; controls: 466.6 [178.0]μg/l). Interestingly, fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy. In agreement with these findings, relative changes (ratio) of FI independently and positively predicted relative changes of irisin (ratio) in the second study population.
The myokine irisin is independently associated with FI in pregnancy. The physiological significance of these findings needs to be assessed in future experiments.
鸢尾素最近被作为一种新型的运动诱导性肌动蛋白而被引入，它可改善小鼠的葡萄糖代谢。然而，迄今为止，尚未评估妊娠期糖尿病（GDM）及围产期循环鸢尾素的调节情况。
对74例GDM患者和74例健康、怀孕、孕周匹配的对照者的循环鸢尾素进行定量分析。在这些患者的一个亚组（44例GDM患者，41例对照者）中，也可获得产后随访数据。在第二项研究人群中，对40例接受择期剖宫产的单胎妊娠健康女性，在分娩前及分娩后24小时内的母血血清、脐血及胎盘组织中评估鸢尾素水平。
在第一项研究人群中，GDM患者产后的鸢尾素水平中位数[四分位间距]显著高于对照组（既往GDM患者：446.3[146.9]μg/l；对照组：378.0[111.4]μg/l），但孕期并非如此（GDM患者：482.1[132.1]μg/l；对照组：466.6[178.0]μg/l）。有趣的是，在多变量分析中，孕期空腹胰岛素（FI）与血清鸢尾素独立且呈正相关。与这些发现一致，在第二项研究人群中，FI的相对变化（比值）独立且呈正性预测鸢尾素的相对变化（比值）。
肌动蛋白鸢尾素在孕期与FI独立相关。这些发现的生理意义需要在未来的实验中进行评估。
