Cullen Breda, Brennan David, Manly Tom, Evans Jonathan J
Mental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Department of Clinical Physics, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
PLoS One. 2016 Jan 29;11(1):e0148127. doi: 10.1371/journal.pone.0148127. eCollection 2016.
Goal neglect is a significant problem following brain injury, and is a target for rehabilitation. It is not yet known how neural activation might change to reflect rehabilitation gains. We developed a computerised multiple elements test (CMET), suitable for use in neuroimaging paradigms.
Pilot correlational study and event-related fMRI study.
In Study 1, 18 adults with acquired brain injury were assessed using the CMET, other tests of goal neglect (Hotel Test; Modified Six Elements Test) and tests of reasoning. In Study 2, 12 healthy adults underwent fMRI, during which the CMET was administered under two conditions: self-generated switching and experimenter-prompted switching.
Among the clinical sample, CMET performance was positively correlated with both the Hotel Test (r = 0.675, p = 0.003) and the Modified Six Elements Test (r = 0.568, p = 0.014), but not with other clinical or demographic measures. In the healthy sample, fMRI demonstrated significant activation in rostro-lateral prefrontal cortex in the self-generated condition compared with the prompted condition (peak 40, 44, 4; ZE = 4.25, p(FWEcorr) = 0.026).
These pilot studies provide preliminary evidence towards the validation of the CMET as a measure of goal neglect. Future studies will aim to further establish its psychometric properties, and determine optimum pre- and post-rehabilitation fMRI paradigms.
目标忽视是脑损伤后一个严重的问题，也是康复治疗的一个靶点。目前尚不清楚神经激活如何变化以反映康复效果。我们开发了一种适用于神经影像学范式的计算机化多元素测试（CMET）。
先导性相关性研究和事件相关功能磁共振成像研究。
在研究1中，使用CMET、目标忽视的其他测试（酒店测试；改良六元素测试）和推理测试对18名获得性脑损伤的成年人进行评估。在研究2中，12名健康成年人接受功能磁共振成像检查，在此期间，在两种条件下进行CMET：自我生成切换和实验者提示切换。
在临床样本中，CMET表现与酒店测试（r = 0.675，p = 0.003）和改良六元素测试（r = 0.568，p = 0.014）均呈正相关，但与其他临床或人口统计学指标无关。在健康样本中，功能磁共振成像显示，与提示条件相比，自我生成条件下额前外侧皮质有显著激活（峰值40、44,4；ZE = 4.25，p(FWEcorr) = 0.026）。
这些先导性研究为验证CMET作为目标忽视的一种测量方法提供了初步证据。未来的研究旨在进一步确定其心理测量特性，并确定康复前后功能磁共振成像的最佳范式。
