Lubec G
Universitäts-Kinderklinik, Wien.
Padiatr Padol. 1989;24(3):227-36.
447 children between 0 and 24 months with diaper dermatitis were treated by topical application of Parfenac-Fettsalbe (Bufexamac). This panel was selected out of 844 patients which were originally in the protocol. The Parfenac-Fettsalbe was well tolerated, 7 children presented local side effects. 62.71% of treated girls showed very good results, whereas 59.89% of boys showed this outcome. Good results were obtained in 24.35% of girls and 21.93% of boys. Very good (no efflorescences remaining) and good results (some remaining efflorescences) were thus found in more than 80% of patients treated: with respect to corticosteroid advoidance this can be regarded as an effective antiphlogistic medication for diaper dermatitis. Non responders might have been superinfected with microorganisms as candida and staphylococci. In addition, epidemiological considerations are reported in that study.
对447名0至24个月患有尿布疹的儿童局部涂抹帕芬那克软膏(丁苯羟酸)进行治疗。该样本是从最初方案中的844名患者中挑选出来的。帕芬那克软膏耐受性良好,7名儿童出现局部副作用。接受治疗的女孩中有62.71%效果非常好,而男孩中这一比例为59.89%。女孩中有24.35%、男孩中有21.93%取得了良好效果。因此,在超过80%接受治疗的患者中发现了非常好(皮疹完全消退)和良好(仍有一些皮疹)的效果:就避免使用皮质类固醇而言,这可被视为治疗尿布疹的一种有效的消炎药物。无反应者可能已被念珠菌和葡萄球菌等微生物重叠感染。此外,该研究还报告了流行病学方面的考量。