Trabelsi M, Mokrani R, Bennaceur B
Service de pédiatrie, hôpital d'Enfants, Tunis, Jebbari, Tunisie.
Pediatrie. 1989;44(5):413-8.
The authors report a retrospective study of 71 cases of Guillain-Barré syndrome in children. The sex ratio was 1.2/1 and the mean age 5.5 years. A history of infection preceded the polyradiculoneuritis in 50% of the cases. Sudden onset was observed in 65%. The mean duration of extensive phase was 6 days (1-20) and the mean duration of the maximum paralysis was 18 days (3-90). A quadriplegia was present in 30 cases, a severe respiratory involvement in 6 cases, a cranial nerve paralysis in 7 cases. An early raised cerebrospinal fluid protein concentration was found in 73%. The motility recuperation time was one month in 53%. A one year follow-up was obtained in 45 patients and 62% had completely recovered clinically. Four patients died, two from respiratory failure, one from autonomic neuropathy, and one from cerebral haemorrhage with associated idiopathic thrombocytopenic purpura. Thirty-two children were followed-up during 3 years and more, 10 (31%) had residual deficits. The functional prognostic factors were the age, the duration of the extension phase and of the plateau phase.
作者报告了一项对71例儿童吉兰 - 巴雷综合征的回顾性研究。男女比例为1.2/1,平均年龄5.5岁。50%的病例在多发性神经根神经炎之前有感染史。65%的病例为突然起病。广泛期的平均持续时间为6天(1 - 20天),最大瘫痪的平均持续时间为18天(3 - 90天)。30例出现四肢瘫痪,6例有严重的呼吸受累,7例有颅神经麻痹。73%的患者脑脊液蛋白浓度早期升高。53%的患者运动恢复时间为1个月。45例患者进行了1年随访,62%的患者临床完全恢复。4例患者死亡,2例死于呼吸衰竭,1例死于自主神经病变,1例死于脑出血合并特发性血小板减少性紫癜。32例儿童随访3年及以上,10例(31%)有残留缺陷。功能预后因素为年龄、扩展期和平台期的持续时间。