From the *Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; and †Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China.
Clin Nucl Med. 2016 Aug;41(8):632-3. doi: 10.1097/RLU.0000000000001134.
Neuroblastoma is among the most common extracranial solid tumors in pediatric patients and typically arises anywhere from the neck to pelvis but most commonly in the adrenal glands. It is extremely rare for a patient to have extensive metastases from neuroblastoma without primary tumor being identified. We present a 3-year-old with widespread bone and bone marrow involvement of the disease revealed on both FDG PET/CT and MIBG scan, which was pathologically proven as neuroblastoma. However, extensive imaging did not detect primary tumor anywhere.
神经母细胞瘤是儿童患者中最常见的颅外实体瘤之一，通常发生在颈部到骨盆的任何部位，但最常见于肾上腺。患者在没有发现原发肿瘤的情况下发生广泛的神经母细胞瘤转移极为罕见。我们介绍了一名 3 岁儿童，其疾病在 FDG PET/CT 和 MIBG 扫描上均显示广泛的骨骼和骨髓受累，经病理证实为神经母细胞瘤。然而，广泛的影像学检查并未在任何部位发现原发肿瘤。
