Huang Can, Jiang Shayi, Liao Xuelian, Li Yanhua, Li Shanshan, Yang Jingwei
Department of Hematology and Oncology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Medicine (Baltimore). 2020 Oct 2;99(40):e22505. doi: 10.1097/MD.0000000000022505.
Neuroblastoma (NB) can occur in any part of the sympathetic nervous system, and it is highly heterogeneous. Tumors that only involve bone marrow and bone lesions without solid masses have rarely been reported.
A 2-year-old girl child presented with recurrent fever, accompanied by pain in both lower limbs for more than 1 month.
Bone marrow examination revealed NB cell invasion. Femoral and multiple vertebral lesions were observed by MRI, while head MRI, chest CT, abdominal CT, and pelvic CT showed no solid mass.
The child received the standard therapy for high-risk NB.
She was sensitive to the initial chemotherapy protocol. Two years later, a bone marrow examination confirmed NB recurrence.
The prognosis of this special type of NB was not improved mainly based on common chemotherapy and local radiotherapy, and new treatment strategies should be explored.
神经母细胞瘤（NB）可发生于交感神经系统的任何部位，且具有高度异质性。仅累及骨髓和骨病变而无实体肿块的肿瘤鲜有报道。
一名2岁女童出现反复发热，并伴有双下肢疼痛1个多月。
骨髓检查发现NB细胞浸润。MRI观察到股骨和多个椎体病变，而头部MRI、胸部CT、腹部CT和盆腔CT均未显示实体肿块。
该患儿接受了高危NB的标准治疗。
她对初始化疗方案敏感。两年后，骨髓检查证实NB复发。
这种特殊类型的NB的预后主要基于常规化疗和局部放疗并未得到改善，应探索新的治疗策略。
