离子对跨膜转运。
Ion pair transport across membranes.
作者信息
Neubert R
机构信息
Sektion Pharmazie, Martin-Luther-Universität, DDR, Halle/Saale.
出版信息
Pharm Res. 1989 Sep;6(9):743-7. doi: 10.1023/a:1015963128124.
PMID:2682590
Abstract
The present review discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown to effectively increase the lipophilicity and transport rate of polar drugs across lipid membranes. The proposed mechanisms of IPT are discussed in detail. A marked change in drug properties upon ion pair formation is necessary to improve the bioavailability of hydrophilic ionizable drugs.
摘要
本综述讨论了适用于离子对转运（IPT）的药物和反离子。研究表明，离子对可有效提高极性药物跨脂质膜的亲脂性和转运速率。文中详细讨论了IPT的潜在机制。为提高亲水性可电离药物的生物利用度，离子对形成后药物性质的显著变化是必要的。
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