Bonichon F, Buy X, Godbert Y, Pointillart V, Henriques de Figueiredo B, Gangi A, Palussière J
Department of nuclear medicine, Institut Bergonie, 229, cours de l'Argonne, 33000 Bordeaux, France.
Department of interventinal radiology, Institut Bergonie, 229, cours de l'Argonne, 33000 Bordeaux, France.
Ann Endocrinol (Paris). 2015 Feb;76(1 Suppl 1):1S40-6. doi: 10.1016/S0003-4266(16)30013-0.
To study the various local treatments available for thyroid cancer metastases, investigate techniques and assess their advantages and limitations and roles in the overall treatment strategy for metastatic disease.
We investigated metastases surgery, external radiation therapy, embolization, chemoembolization, cementoplasty, radiofrequency ablation and cryotherapy, describing techniques, advantages and drawbacks and possible complications. Indications were reviewed according to metastases location, and the roles of the various techniques are discussed in the overall treatment strategy for thyroid cancer metastases. Despite the advent of new targeted therapies, local treatment still has an important role to play: either palliative or, in oligometastatic involvement, curative. Even in extensive disease, it may allow postponement of tyrosine kinase inhibitor therapy, which, once initiated, has to be continued life-long, is expensive and is not free of side-effects.
研究甲状腺癌转移灶可用的各种局部治疗方法，探讨其技术，评估其优缺点以及在转移性疾病整体治疗策略中的作用。
我们研究了转移灶手术、外照射放疗、栓塞、化疗栓塞、骨水泥成形术、射频消融和冷冻治疗，描述了技术、优缺点及可能的并发症。根据转移灶位置对适应证进行了综述，并在甲状腺癌转移灶的整体治疗策略中讨论了各种技术的作用。尽管出现了新的靶向治疗方法，但局部治疗仍发挥着重要作用：无论是姑息性治疗，还是在寡转移情况下的根治性治疗。即使在广泛转移的疾病中，局部治疗也可能允许推迟酪氨酸激酶抑制剂治疗，因为一旦开始使用该治疗，就必须终身持续，费用高昂且并非没有副作用。
