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病例报告:1例罕见的继发于甲状腺乳头状癌的乳腺及多器官转移病例。

Case report: A rare case of breast and multiorgan metastases secondary to papillary thyroid carcinoma.

作者信息

Huang Wenqin, Yang Yalong, Zhan Peng, Jiang Liang, Chen Jian, Zheng Hongmei

机构信息

Department of Breast Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, National Key Clinical Specialty Construction Discipline, Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan Clinical Research Center for Breast Cancer, Wuhan, Hubei, China.

Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Front Oncol. 2024 Nov 4;14:1422817. doi: 10.3389/fonc.2024.1422817. eCollection 2024.

DOI:10.3389/fonc.2024.1422817
PMID:39558959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11570576/
Abstract

Papillary thyroid carcinoma (PTC) is generally considered a highly indolent endocrine malignancy, often accompanied by cervical lymph node metastasis and rarely involving distant metastases. We present a rare case of a 37-year-old woman with PTC, who exhibited regional lymph node metastasis, right breast metastasis, and probable right psoas major and multiple bone metastases. Initial symptoms included hoarseness, and subsequent examination revealed a secondary malignant tumor in the right breast, originating from the thyroid gland. This case highlights an unusual pattern of multiple systemic metastasis in PTC, particularly the rare occurrence of breast metastasis.

摘要

甲状腺乳头状癌(PTC)通常被认为是一种惰性很强的内分泌恶性肿瘤,常伴有颈部淋巴结转移,很少发生远处转移。我们报告一例罕见的37岁PTC女性病例,该患者出现区域淋巴结转移、右乳转移以及可能的右腰大肌和多处骨转移。初始症状为声音嘶哑,随后检查发现右乳有一处继发恶性肿瘤,起源于甲状腺。该病例突出了PTC罕见的多系统转移模式,尤其是罕见的乳腺转移情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/35969932b34a/fonc-14-1422817-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/251fa5ca3918/fonc-14-1422817-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/5dec6679b838/fonc-14-1422817-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/35969932b34a/fonc-14-1422817-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/251fa5ca3918/fonc-14-1422817-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/5dec6679b838/fonc-14-1422817-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d572/11570576/35969932b34a/fonc-14-1422817-g003.jpg

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本文引用的文献

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Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy.晚期分化型甲状腺癌的放射性碘治疗:耐药性与克服策略。
Drug Resist Updat. 2023 May;68:100939. doi: 10.1016/j.drup.2023.100939. Epub 2023 Feb 8.
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Papillary Thyroid Carcinoma With Breast and Bone Metastasis.甲状腺乳头状癌伴乳腺和骨转移。
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Genetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High Mutation Allele Frequency, Multiple Driver Gene Mutations, and Fusion May Indicate More Advanced TN Stage.
中国人群甲状腺乳头状癌的遗传和临床病理特征:高突变等位基因频率、多个驱动基因突变和融合可能提示更高级别的TN分期。
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The importance of the RET gene in thyroid cancer and therapeutic implications.RET 基因在甲状腺癌中的重要性及其治疗意义。
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The Benefit of Primary Tumor Surgical Resection in Distant Metastatic Carcinomas of the Thyroid.甲状腺远处转移癌行原发灶手术切除的获益。
Laryngoscope. 2021 May;131(5):1026-1034. doi: 10.1002/lary.29053. Epub 2020 Aug 31.
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Solitary Breast Metastasis From Thyroid Papillary Carcinoma Revealed on Whole-Body Radioactive 131I Scan.全身放射性碘 131I 扫描发现甲状腺乳头状癌单发乳房转移。
Clin Nucl Med. 2020 Sep;45(9):687-688. doi: 10.1097/RLU.0000000000003115.
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Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.甲状腺癌:ESMO 诊断、治疗及随访临床实践指南†
Ann Oncol. 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400.
8
Local treatment of metastases from differentiated thyroid cancer.分化型甲状腺癌转移灶的局部治疗。
Ann Endocrinol (Paris). 2015 Feb;76(1 Suppl 1):1S40-6. doi: 10.1016/S0003-4266(16)30013-0.
9
TERT promoter mutations in thyroid cancer.甲状腺癌中的端粒酶逆转录酶(TERT)启动子突变
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10
Papillary thyroid carcinoma in Denmark, 1996-2008: outcome and evaluation of established prognostic scoring systems in a prospective national cohort.丹麦 1996-2008 年的甲状腺乳头状癌:前瞻性全国队列中对既定预后评分系统的评估和结果。
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