潜在恶性口腔疾病和口腔鳞状细胞癌中唾液爱泼斯坦-巴尔病毒的患病率。
Prevalence of salivary Epstein-Barr virus in potentially malignant oral disorders and oral squamous cell carcinoma.
作者信息
Bagan Leticia, Ocete-Monchon María-Dolores, Leopoldo-Rodado Manuel, Murillo-Cortes Judith, Díaz-Fernández Jose-M, Medina-Gonzalez Rafael, Gimeno-Cardona Concepción, Bagan Jose-V
机构信息
Oral Medicine Department, C/ Gasco Oliag 1, 46010 Valencia, Spain,
出版信息
Med Oral Patol Oral Cir Bucal. 2016 Mar 1;21(2):e157-60. doi: 10.4317/medoral.20785.
BACKGROUND
To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders.
MATERIAL AND METHODS
Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR.
RESULTS
The highest percentage of positive salivary EBV DNA corresponded to the OSCC group (58.3%), followed by the PMD group (41.7%) and the controls (40.4%). The differences between groups were not statistically significant, however (p>0.05).
CONCLUSIONS
Salivary EBV DNA was more prevalent in OSCC than in PMD or the controls.
背景
分析口腔鳞状细胞癌和潜在恶性口腔疾病中唾液 Epstein-Barr 病毒（EBV）DNA 的存在情况。
材料与方法
研究分为三组：第 1 组（12 例口腔鳞状细胞癌（OSCC））、第 2 组（12 例潜在恶性口腔疾病（PMD））和第 3 组（47 例健康对照）。通过聚合酶链反应（PCR）对唾液中的 EBV DNA 进行分析。
结果
唾液 EBV DNA 阳性率最高的是 OSCC 组（58.3%），其次是 PMD 组（41.7%）和对照组（40.4%）。然而，各组之间的差异无统计学意义（p>0.05）。
结论
唾液 EBV DNA 在 OSCC 中比在 PMD 或对照组中更普遍。
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