Bagan Jose V, Jiménez Yolanda, Murillo Judith, Poveda Rafael, Díaz José M, Gavaldá Carmen, Margaix María, Scully Crispian, Alberola Trinidad M, Torres Puente Manuela, Pérez Alonso Manuel
Oral Medicine, Valencia University, Department of Stomatology, University General Hospital, Valencia, Spain.
Med Oral Patol Oral Cir Bucal. 2008 Feb 1;13(2):E110-3.
The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of Sub-Group 3 (controls).
本研究的目的是分析增殖性疣状白斑(PVL)和口腔鳞状细胞癌(OSCC)中是否可能存在爱泼斯坦-巴尔病毒(EBV)。我们研究了三组:第一亚组由10例PVL患者组成(其中6例已发展为OSCC);第二亚组包括5例无先前PVL的OSCC患者;第三亚组为5名口腔黏膜临床正常的对照者。通过巢式聚合酶链反应(nested PCR)对所有病例的口腔活检组织进行爱泼斯坦-巴尔病毒(EBV)检测。在第一亚组(PVL)60%的患者、第二亚组(OSCC)40%的患者中检测到EBV,但在第三亚组(对照者)中未检测到(0%)。