miR-489-5p对GSE1的负调控促进乳腺癌细胞增殖和侵袭。
GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion.
作者信息
Chai Peng, Tian Jingzhong, Zhao Deyin, Zhang Hongyan, Cui Jian, Ding Keshuo, Liu Bin
机构信息
Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China.
Department of General Surgery, The People's Hospital of Bozhou, Bozhou 236800, PR China.
出版信息
Biochem Biophys Res Commun. 2016 Feb 26;471(1):123-8. doi: 10.1016/j.bbrc.2016.01.168. Epub 2016 Jan 30.
Gse1 coiled-coil protein (GSE1), also known as KIAA0182, is a proline rich protein. However, the function of GSE1 is largely unknown. In this study, we reported that GSE1 is overexpression in breast cancer and silencing of GSE1 significantly suppressed breast cancer cells proliferation, migration and invasion. Furthermore, GSE1 was identified as a direct target of miR-489-5p, which is significantly reduced in breast cancer tissues. In addition, forced expression of miR-489-5p suppressed breast cancer cells proliferation, migration and invasion. Moreover, depletion of GSE1 by siRNAs significantly abrogated the enhanced proliferation, migration and invasion of breast cancer cells consequent to miR-489-5p depletion. Taken together, these findings suggest that GSE1 may function as a novel oncogene in breast cancer and it can be regulated by miR-489-5p.
Gse1卷曲螺旋蛋白（GSE1），也被称为KIAA0182，是一种富含脯氨酸的蛋白质。然而，GSE1的功能在很大程度上尚不清楚。在本研究中，我们报道GSE1在乳腺癌中过表达，沉默GSE1可显著抑制乳腺癌细胞的增殖、迁移和侵袭。此外，GSE1被鉴定为miR-489-5p的直接靶点，而miR-489-5p在乳腺癌组织中显著降低。另外，强制表达miR-489-5p可抑制乳腺癌细胞的增殖、迁移和侵袭。此外，通过小干扰RNA（siRNAs）耗尽GSE1可显著消除因miR-489-5p耗尽而导致的乳腺癌细胞增殖、迁移和侵袭增强。综上所述，这些发现表明GSE1可能作为一种新型癌基因在乳腺癌中发挥作用，并且它可受miR-489-5p调控。
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