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[多发性胃类癌、萎缩性胃炎、高胃泌素血症:一种已证实的关联(一例新病例)]

[Multiple gastric carcinoids, atrophic gastritis, hypergastrinemia: a confirmed association (a new case)].

作者信息

González Martín J A, De Miguel R, Martínez Montiel M P, Pérez Sola A, Razquin J, Calvo A, Saiz F

出版信息

Rev Esp Enferm Apar Dig. 1989 Aug;76(2):161-4.

PMID:2682832
Abstract

Although carcinoid tumors only infrequently (2-6%) have a gastric localization, in recent years several cases have been described of this tpe of neoplasm in association with atrophic gastritis (with or without pernicious anemia). A possible carcinogenetic effect of sustained hypergastrinemia on the enterochromaffin-like cells (ECL) of the gastric mucosa has been postulated. A new case of these characteristics in reported, and a review is made of the pathogenic hypotheses in the literature on this peculiar type of tumors and their possible clinical implications.

摘要

尽管类癌肿瘤很少(2%-6%)发生于胃部,但近年来已有数例这种类型的肿瘤与萎缩性胃炎(伴或不伴恶性贫血)相关的病例被报道。有人推测持续高胃泌素血症对胃黏膜肠嗜铬样细胞(ECL)可能具有致癌作用。本文报告了1例具有这些特征的新病例,并对关于这类特殊肿瘤的文献中的致病假说及其可能的临床意义进行了综述。

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