Moreno Sánchez D, Medina Asensio J, Colina Ruiz-Delgado F, Campos Cantero R, Crespo Rincón L, Belda Serna A
Rev Esp Enferm Apar Dig. 1989 Sep;76(3):273-6.
Carbimazole, an antithyroid agent of the thioimidazole group, can induce unpredictable liver alterations, presumably by hypersensitivity. We describe the case of a hyperthyroid woman who suffered acute submassive cholestatic hepatitis in the course of treatment with this drug. We also review the other seven cases of carbimazole hepatotoxicity previously communicated in the literature.
甲巯咪唑是硫代咪唑类抗甲状腺药物,可能通过超敏反应诱发不可预测的肝脏改变。我们描述了一名甲状腺功能亢进女性在使用该药物治疗过程中发生急性亚大块胆汁淤积性肝炎的病例。我们还回顾了文献中先前报道的其他7例甲巯咪唑肝毒性病例。