Lisowska Anna, Knapp Małgorzata, Tycińska Agnieszka, Motybel Elżbieta, Kamiński Karol, Święcki Przemysław, Musiał Włodzimierz J, Dymicka-Piekarska Violetta
Department of Cardiology, Medical University, Ul. Sklodowskiej 24A, 15-276 Bialystok, Poland.
Department of Cardiology, Medical University, Ul. Sklodowskiej 24A, 15-276 Bialystok, Poland.
Atherosclerosis. 2016 Mar;246:309-17. doi: 10.1016/j.atherosclerosis.2016.01.022. Epub 2016 Jan 14.
The role of Galectin-3(Gal-3) in atherosclerosis progression has not been definitely acknowledged. The aim of the study was to establish the following: whether Gal-3 may act as an independent risk factor of coronary artery disease (CAD) occurrence and its advancement, if Gal-3 has potential relations with classical and new markers of cardiovascular risk (carotid intima-media thickness (cIMT), and whether Gal-3 may be a marker of mortality in the group of patients with myocardial infarction (MI) during mid-term follow-up.
The study group was composed of 233 patients with MI and 100 patients with a stable CAD. Selected risk factors were assessed, Gal-3 concentrations and cIMT were measured. The control group was composed of 100 healthy individuals.
In the study group (MI and CAD patients) Gal-3 concentration was significantly higher than in the controls--median 7.9 ng/ml (p = 0.0001) and 10.7 ng/ml (p = 0.00001) vs. 5.5 ng/ml, respectively. Patients with 3-vessel disease had higher levels of Gal-3 than patients with 1-or 2-vessel disease (9.2 ng/ml vs 7.4 ng/ml, p = 0.003). In the group of MI patients who died during the follow-up (average period - 2.8 years), we found a significantly higher concentration of Gal-3 (20.0 ng/ml vs 8.0 ng/ml, p = 0.0005) and cIMT values (common carotid artery(CCA): 1.4 ± 0.4 mm vs. 1.0 ± 0.3 mm, p = 0.03; carotid bulb(CB): 2.3 ± 0.5 mm vs. 1.9 ± 0.4 mm, p = 0.009). In the model of multivariate logistic regression analysis, the variables influencing the mortality after MI during follow-up were: age>65 years, Gal-3 concentration>8.7 ng/ml, IMT values and plaque occurrence in CB, previous MI and EF<40%.
Gal-3 is an independent risk factor of CAD occurrence, but cIMT values are better markers of CAD advancement. Both Gal-3 concentration>8.7 ng/ml and IMT values in CB were an independent predictive indicators of increased risk of all-cause mortality in patients after MI during mid-term follow up.
半乳糖凝集素-3（Gal-3）在动脉粥样硬化进展中的作用尚未得到明确认可。本研究的目的是确定以下内容：Gal-3是否可能作为冠状动脉疾病（CAD）发生及其进展的独立危险因素，Gal-3与心血管风险的经典和新标志物（颈动脉内膜中层厚度（cIMT））是否存在潜在关系，以及Gal-3是否可能是心肌梗死（MI）患者中期随访期间死亡的标志物。
研究组由233例MI患者和100例稳定型CAD患者组成。评估了选定的危险因素，测量了Gal-3浓度和cIMT。对照组由100名健康个体组成。
在研究组（MI和CAD患者）中，Gal-3浓度显著高于对照组——中位数分别为7.9 ng/ml（p = 0.0001）和10.7 ng/ml（p = 0.00001），而对照组为5.5 ng/ml。三支血管病变患者的Gal-3水平高于单支或双支血管病变患者（9.2 ng/ml对7.4 ng/ml，p = 0.003）。在随访期间死亡的MI患者组（平均随访期 - 2.8年）中，我们发现Gal-3浓度显著更高（20.0 ng/ml对8.0 ng/ml，p = 0.0005）以及cIMT值更高（颈总动脉（CCA）：1.4±0.4 mm对1.0±0.3 mm，p = 0.03；颈动脉窦（CB）：2.3±0.5 mm对1.9±0.4 mm，p = 0.009）。在多因素逻辑回归分析模型中，影响MI患者随访期间死亡率的变量为：年龄>65岁、Gal-3浓度>8.7 ng/ml、IMT值和CB处斑块的出现、既往MI以及射血分数<40%。
Gal-3是CAD发生的独立危险因素，但cIMT值是CAD进展的更好标志物。Gal-3浓度>8.7 ng/ml和CB处的IMT值均是MI患者中期随访期间全因死亡风险增加的独立预测指标。
