Kaiser L
Biometrics Department, Sterling-Winthrop Research Institute, Rensselaer, New York 12144.
Stat Med. 1989 Oct;8(10):1183-90. doi: 10.1002/sim.4780081002.
Clinical trials data often include baseline and response measurements on each patient. Comparisons of treatments commonly employ either change from baseline or percentage change from baseline as the analysis variable. This paper provides guidance on the choice between these two by means of plots of these variables versus baseline. I provide two examples that illustrate the problem and I discuss the impact of use of the wrong adjusted response.
临床试验数据通常包括每位患者的基线测量值和反应测量值。治疗方法的比较通常采用相对于基线的变化量或相对于基线的百分比变化量作为分析变量。本文通过将这些变量与基线进行绘图的方式，为在这两者之间做出选择提供指导。我给出两个例子来说明这个问题，并讨论使用错误的调整后反应的影响。
