Thase Michael E
Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, 3535 Market St, Philadelphia, PA 19104
J Clin Psychiatry. 2016 Feb;77 Suppl 1:22-7. doi: 10.4088/JCP.14077su1c.04.
Medical comorbidities contribute to poor antidepressant response, treatment resistance, and poor outcomes in many patients with depression. Depression can co-occur with thyroid conditions, chronic pain conditions, central nervous system disorders, and more. Inflammatory conditions such as diabetes and obesity are also associated with depression, and the connection between inflammation and depression may lead to testing that could better match patients to specific antidepressant treatment. Interventions for patients with depression and a comorbid medical condition include careful selection of antidepressant therapy as well as psychotherapy and adjunctive agents.
在许多抑郁症患者中，合并的内科疾病会导致抗抑郁药反应不佳、治疗抵抗及预后不良。抑郁症可能与甲状腺疾病、慢性疼痛疾病、中枢神经系统疾病等同时出现。糖尿病和肥胖等炎症性疾病也与抑郁症有关，炎症与抑郁症之间的联系可能会促使进行相关检测，以便能更好地为患者匹配特定的抗抑郁治疗。针对患有抑郁症及合并内科疾病的患者的干预措施包括谨慎选择抗抑郁治疗、心理治疗以及辅助药物。
