从土壤中分离人类真菌并鉴定新型隐球菌和粗球孢子菌的两个地方流行区域。

Isolation of human fungi from soil and identification of two endemic areas of Cryptococcus neoformans and Coccidioides immitis.

作者信息

Rubinstein H, Marticorena B, Masih D, Borletto N, Vega R, Varengo H, Negroni R

出版信息

Rev Inst Med Trop Sao Paulo. 1989 Jan-Feb;31(1):1-6. doi: 10.1590/s0036-46651989000100001.

DOI:10.1590/s0036-46651989000100001

Abstract

The present study was carried out in two different areas of Province of Cordoba, Argentina, where there was a suspicious of endemic mycosis. The previous data were the presence of a clinical case of pulmonary cryptococcosis in one area (Alta Gracia) and the previous findings of a high incidence of coccidioidin and cryptococcin reactors in the population of the second one (Villa Dolores). In both areas soil samples for fungi were studied and Cryptococcus neoformans was found in 2/25 samples from Alta Gracia. In Villa Dolores Coccidioides immitis was isolated in 2/40 samples, and C. neoformans in 1/40 samples. Delayed hypersensitivity test with cryptococcin was determined in the population from Alta Gracia and it was found to be 5.3%. Positive cutaneous tests with coccidioidin (33.8%) and cryptococcin (31.9%) in Villa Dolores were obtained. With these findings two endemic areas of systemic mycoses in Cordoba, Argentina were delimited.

摘要

本研究在阿根廷科尔多瓦省的两个不同地区开展，这两个地区存在地方性真菌病疑似情况。先前的数据是，在一个地区（阿尔塔格拉西亚）有1例肺隐球菌病临床病例，以及在第二个地区（比利亚多洛雷斯）人群中先前发现球孢子菌素和隐球菌素反应者的高发病率。在这两个地区都对真菌的土壤样本进行了研究，在阿尔塔格拉西亚的25份样本中有2份发现了新型隐球菌。在比利亚多洛雷斯，40份样本中有2份分离出粗球孢子菌，40份样本中有1份分离出新型隐球菌。对阿尔塔格拉西亚的人群进行了隐球菌素迟发型超敏反应试验，结果为5.3%。在比利亚多洛雷斯获得了球孢子菌素（33.8%）和隐球菌素（31.9%）阳性皮肤试验结果。根据这些发现，划定了阿根廷科尔多瓦省的两个系统性真菌病流行区。