通过氢膦酸酯实现α,β-不饱和羰基化合物中C═C或Csp(2)-C(CO)键的取代基控制化学选择性裂解，生成β-酮膦酸酯。
Substituent-Controlled Chemoselective Cleavage of C═C or Csp(2)-C(CO) Bond in α,β-Unsaturated Carbonyl Compounds with H-Phosphonates Leading to β-Ketophosphonates.
作者信息
Zhou Yao, Rao Changqing, Mai Shaoyu, Song Qiuling
机构信息
Institute of Next Generation Matter Transformation, College of Chemical Engineering, College of Materials Science & Engineering, Huaqiao University , 668 Jimei Blvd, Xiamen, Fujian 361021, P. R. China.
出版信息
J Org Chem. 2016 Mar 4;81(5):2027-34. doi: 10.1021/acs.joc.5b02887. Epub 2016 Feb 16.
An unprecedented substituent-controlled chemoselective cleavage of C═C double bond or C(sp(2))-C(CO) bond along with aerobic phosphorylation of α,β-unsaturated carbonyl compounds with H-phosphonates through a radical process has been disclosed. The current strategy provides an access to β-ketophosphonates under mild conditions with a wide substrate scope.
已公开了一种前所未有的、通过自由基过程实现的、受取代基控制的化学选择性裂解碳碳双键或碳（sp(2)）-碳（羰基）键，同时使α,β-不饱和羰基化合物与H-膦酸酯进行需氧磷酸化反应的方法。当前策略在温和条件下提供了一种制备β-酮膦酸酯的途径，底物范围广泛。
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