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用于抗菌应用的多糖基纳米材料的最新进展。

An update on polysaccharide-based nanomaterials for antimicrobial applications.

作者信息

Arora Divya, Sharma Nisha, Sharma Vishal, Abrol Vidushi, Shankar Ravi, Jaglan Sundeep

机构信息

Quality Control & Quality Assurance Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, , 180001, India.

CSIR-Academy of Scientific & Innovative Research, Govt. of India, New Delhi, India.

出版信息

Appl Microbiol Biotechnol. 2016 Mar;100(6):2603-15. doi: 10.1007/s00253-016-7315-0. Epub 2016 Jan 30.

Abstract

Scientific community has made a lot of efforts to combat the infectious diseases using antimicrobial agents, but these are associated with problems of development of multi-drug resistance and their adverse side effects. To tackle these challenges, nanocarrier-based drug delivery system using polysaccharides has received enormous attention in the past few years. These antimicrobial agents can become more efficacious when adsorbed, entrapped, or linked to polysaccharides. In addition, these nanocarrier-based systems provide an increase in the surface area of the drug and are able to achieve the targeted drug delivery as well as used for the synthesis of packaging materials with improved mechanical strength, barrier, and antimicrobial properties. This review focuses on potential therapeutic applications of nanocarrier-based drug delivery systems using polysaccharides for antimicrobial applications.

摘要

科学界已做出诸多努力,使用抗菌剂来对抗传染病,但这些抗菌剂存在多重耐药性发展问题及其不良副作用。为应对这些挑战,在过去几年中,基于多糖的纳米载体药物递送系统受到了极大关注。当这些抗菌剂被吸附、包封或与多糖连接时,它们会变得更有效。此外,这些基于纳米载体的系统增加了药物的表面积,能够实现靶向药物递送,还可用于合成具有改善的机械强度、阻隔性和抗菌性能的包装材料。本综述聚焦于基于多糖的纳米载体药物递送系统在抗菌应用方面的潜在治疗用途。

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