Manivasagan Panchanathan, Oh Junghwan
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 608-737, Republic of Korea.
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 608-737, Republic of Korea; Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 608-737, Republic of Korea.
Int J Biol Macromol. 2016 Jan;82:315-27. doi: 10.1016/j.ijbiomac.2015.10.081. Epub 2015 Oct 30.
Research on marine polysaccharide-based nanomaterials is emerging in nanobiotechnological fields such as drug delivery, gene delivery, tissue engineering, cancer therapy, wound dressing, biosensors, and water treatment. Important properties of the marine polysaccharides include biocompatibility, biodegradability, nontoxicity, low cost, and abundance. Most of the marine polysaccharides are derived from natural sources such as fucoidan, alginates, carrageenan, agarose, porphyran, ulvan, mauran, chitin, chitosan, and chitooligosaccharide. Marine polysaccharides are very important biological macromolecules that widely exist in marine organisms. Marine polysaccharides exhibit a vast variety of structures and are still under-exploited and thus should be considered as a novel source of natural products for drug discovery. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. Marine polysaccharides have been shown to have a variety of biological and biomedical properties. Recently, research and development of marine polysaccharide-based nanomaterials have received considerable attention as one of the major resources for nanotechnological applications. This review highlights the recent research on marine polysaccharide-based nanomaterials for biotechnological and biomedical applications.
基于海洋多糖的纳米材料在药物递送、基因递送、组织工程、癌症治疗、伤口敷料、生物传感器和水处理等纳米生物技术领域的研究正在兴起。海洋多糖的重要特性包括生物相容性、生物降解性、无毒、低成本和丰富性。大多数海洋多糖来源于天然来源，如岩藻聚糖、藻酸盐、卡拉胶、琼脂糖、紫菜聚糖、褐藻糖胶、木耳多糖、几丁质、壳聚糖和壳寡糖。海洋多糖是广泛存在于海洋生物中的非常重要的生物大分子。海洋多糖具有多种多样的结构，仍未得到充分开发，因此应被视为药物发现的新型天然产物来源。可以从藻类、甲壳类动物和微生物等海洋生物中提取种类繁多的多糖。海洋多糖已被证明具有多种生物学和生物医学特性。最近，基于海洋多糖的纳米材料的研究和开发作为纳米技术应用的主要资源之一受到了相当大的关注。本综述重点介绍了基于海洋多糖的纳米材料在生物技术和生物医学应用方面的最新研究。
