Crawley Jacqueline N, Heyer Wolf-Dietrich, LaSalle Janine M
MIND Institute, School of Medicine, University of California Davis, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Department of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA; Comprehensive Cancer Center, University of California Davis, Sacramento, CA, 95817, USA.
Trends Genet. 2016 Mar;32(3):139-146. doi: 10.1016/j.tig.2016.01.001. Epub 2016 Jan 29.
Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
自闭症是一种神经发育障碍，通过社交和沟通缺陷、重复行为以及受限兴趣进行行为学诊断。最近的全基因组外显子测序揭示了自闭症和癌症的风险基因存在广泛重叠。了解自闭症和癌症的遗传共性，重点关注机制途径，可能会带来重新利用的疗法。
