Sayahi Mohammad Hosein, Baghersaei Shirin, Goli Fereshteh, Moghimi Setareh, Mahdavi Mohammad, Firoozpour Loghman, Shafiee Abbas, Foroumadi Alireza
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Comb Chem High Throughput Screen. 2016;19(3):189-92. doi: 10.2174/1386207319666160202120802.
Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.
在此，我们描述了一种制备1,2,3-三嗪并[1,6-a]喹唑啉-13-酮的简单四步方法。该方法包括开环、喹唑啉形成缩合、还原、重氮化，最后一步伴随着快速分子内环化，以优异至高收率得到具有结构复杂杂环核心的所需产物。
