Roy Abhijeet Deb, Subramanian Arunachalam, Roy Raja
Division of SAIF, Central Drug Research Institute, Lucknow 226 001, India.
J Org Chem. 2006 Jan 6;71(1):382-5. doi: 10.1021/jo0518912.
[reaction: see text] A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished the desired tetracyclic product in good yields with high purity.
[反应：见正文] 报道了一种由氯化亚锡介导的简短、高效且实用的区域选择性合成具有三点多样性的双杂环5,6-二氢喹唑啉并[4,3-b]喹唑啉-8-酮的方法。2-(2-硝基苯基)-3H-喹唑啉-4-酮在各种醇中进行一步还原转化，以高纯度和良好产率得到所需的四环产物。
