Gurling H M, Sherrington R P, Brynjolfsson J, Read T, Curtis D, Mankoo B J, Potter M, Petursson H
Academic Department of Psychiatry, University College and Middlesex School of Medicine, London, United Kingdom.
Schizophr Bull. 1989;15(3):373-82. doi: 10.1093/schbul/15.3.373.
The difficulties anticipated in the application of molecular genetics to schizophrenia research have not prevented the first successful localization of a susceptibility gene for a subtype of schizophrenia. It is argued that this approach is the most useful of the possible molecular genetic strategies because it leads both to enhanced clinical genetic investigation and to further recombinant DNA research to clone and sequence schizophrenia susceptibility mutations. Future recombinant DNA research can now use long-range mapping and cloning techniques such as the chromosome walking/jumping approach and the strategy of cloning brain-specific cDNAs from brain mRNA. The identification of carriers for high-risk studies and the genetic validation of diagnosis appear to be the most promising clinical developments. Prenatal counseling will only become widely feasible when much more is known about the extent of heterogeneity of linkage in schizophrenia.
分子遗传学应用于精神分裂症研究中预期会遇到的困难，并未阻止首次成功定位出精神分裂症一个亚型的易感基因。有人认为，这种方法是所有可能的分子遗传学策略中最有用的，因为它既能加强临床遗传学研究，又能推动进一步的重组DNA研究，以克隆和测序精神分裂症的易感突变。未来的重组DNA研究现在可以使用长距离定位和克隆技术，如染色体步移/跳跃法以及从脑信使核糖核酸克隆脑特异性互补脱氧核糖核酸的策略。确定高危研究的携带者以及诊断的基因验证似乎是最有前景的临床进展。只有当对精神分裂症连锁异质性的程度有更多了解时，产前咨询才会广泛可行。
