精神分裂症的分子遗传学研究

Molecular genetic studies in schizophrenia.

作者信息

Kennedy J L, Giuffra L A, Moises H W, Wetterberg L, Sjögren B, Cavalli-Sforza L L, Pakstis A J, Kidd J R, Kidd K K

机构信息

Dept. of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Schizophr Bull. 1989;15(3):383-91. doi: 10.1093/schbul/15.3.383.

DOI:10.1093/schbul/15.3.383

PMID:2573149

Abstract

Despite many years of research, the genetic factors in schizophrenia are not well understood. Recent developments in DNA technology allow new methods of testing genetic hypotheses in the etiology of this debilitating disorder. We have found evidence against linkage of schizophrenia in a Swedish kindred to markers on chromosome 5; another research group has reported positive evidence for linkage to this same chromosomal region in British and Icelandic families. This article presents a set of data expanded from our previous report, discusses the issue of heterogeneity, and reviews the current status of linkage studies in schizophrenia.

摘要

尽管经过多年研究，但精神分裂症的遗传因素仍未得到充分理解。DNA技术的最新进展为检验这种致残性疾病病因中的遗传假说提供了新方法。我们已找到证据，证明瑞典一个家族的精神分裂症与5号染色体上的标记不存在连锁关系；另一个研究小组报告称，在英国和冰岛家庭中发现了与同一染色体区域存在连锁关系的阳性证据。本文展示了一组在我们之前报告基础上扩充的数据，讨论了异质性问题，并综述了精神分裂症连锁研究的现状。