Department of Neonatology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Infection. 2016 Aug;44(4):555-7. doi: 10.1007/s15010-016-0876-0. Epub 2016 Jan 30.
We report on a late-preterm neonate with severe congenital cytomegalovirus (CMV) infection, refractory to antiviral therapy with ganciclovir. Subsequent immune diagnostics led to the finding of HIV infection at day 69, even though the mother tested negative for HIV in early pregnancy. Thus, in congenital CMV infection, HIV testing should be performed to elucidate maternal HIV seroconversion during late pregnancy. Our case strongly supports third trimester screening of HIV infection acquired during pregnancy, yet recommended only for women with traditional risk factors for HIV or living in an area of high HIV prevalence.
我们报告了一例晚期早产儿患有严重先天性巨细胞病毒（CMV）感染，对更昔洛韦的抗病毒治疗有抗药性。随后的免疫诊断发现，患儿在 69 天时感染了 HIV，尽管母亲在早期妊娠时 HIV 检测为阴性。因此，在先天性 CMV 感染中，应进行 HIV 检测以阐明母亲在妊娠晚期 HIV 血清转化。我们的病例强烈支持对妊娠期间获得的 HIV 感染进行第三孕期筛查，但仅推荐给具有 HIV 传统危险因素或生活在 HIV 高发地区的妇女。
