Hansen J T, Sladek J R
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY 14642.
Science. 1989 Nov 10;246(4931):775-9. doi: 10.1126/science.2683082.
This article reviews some of the significant contributions of fetal research and fetal tissue research over the past 20 years. The benefits of fetal research include the development of vaccines, advances in prenatal diagnosis, detection of malformations, assessment of safe and effective medications, and the development of in utero surgical therapies. Fetal tissue research benefits vaccine development, assessment of risk factors and toxicity levels in drug production, development of cell lines, and provides a source of fetal cells for ongoing transplantation trials. Together, fetal research and fetal tissue research offer tremendous potential for the treatment of the fetus, neonate, and adult.
本文回顾了过去20年胎儿研究和胎儿组织研究的一些重大贡献。胎儿研究的益处包括疫苗的研发、产前诊断的进展、畸形的检测、安全有效的药物评估以及子宫内手术治疗的发展。胎儿组织研究有利于疫苗研发、药物生产中风险因素和毒性水平的评估、细胞系的开发,并为正在进行的移植试验提供胎儿细胞来源。胎儿研究和胎儿组织研究共同为胎儿、新生儿和成人的治疗提供了巨大潜力。