Serakinci Nedime, Kalkan Rasime, Tulay Pinar
Faculty of Medicine, Department of Medical Genetics, Near East University, Yakin Dogu Bulvari, Nicosia, Cyprus, Turkey.
Curr Stem Cell Res Ther. 2016;11(4):343-51. doi: 10.2174/1574888x11666160201115733.
Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.
人骨髓间充质干细胞（hMSCs）是多能非造血前体细胞，具有分化为多种组织类型的能力。由于其归巢能力，hMSCs在癌症治疗以及大量退行性疾病治疗中具有重要意义。然而，这些细胞可能会发生自发转化，导致它们绕过自然内置的细胞控制机制，而这些机制可能导致细胞衰老和癌变。因此，尽管间充质干细胞在癌症治疗方面具有巨大潜力，但它们也存在患癌风险，这赋予了它们在癌症发展和治疗方面的双面特性。本文讨论了从hMSCs的体外扩增和端粒动态变化方面来看hMSCs在治疗中的潜在应用。
