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胸主动脉腔内修复术:单中心15年经验

Thoracic endovascular aortic repair: A single center's 15-year experience.

作者信息

Ziza Vincent, Canaud Ludovic, Molinari Nicolas, Branchereau Pascal, Marty-Ané Charles, Alric Pierre

机构信息

Department of Vascular and Thoracic Surgery, Arnaud de Villeneuve University Hospital, Montpellier, France.

Department of Vascular and Thoracic Surgery, Arnaud de Villeneuve University Hospital, Montpellier, France.

出版信息

J Thorac Cardiovasc Surg. 2016 Jun;151(6):1595-1603.e7. doi: 10.1016/j.jtcvs.2015.12.030. Epub 2015 Dec 22.

Abstract

OBJECTIVE

Specific complications of thoracic endovascular aortic repair (TEVAR) exist and long-term data are lacking. The purpose of this study was to evaluate our long-term TEVAR results.

METHODS

This is a single-center retrospective study of 223 patients undergoing TEVAR from 1998 to 2013. Indication was aneurysm (45%), traumatic (26%), dissection (23%), and septic (6%).

RESULTS

Patients' mean age was 62.7 ± 17.9 years, 84% of them had an American Society of Anesthesiologists score ≥3, and 42% had an aortic rupture. TEVAR was performed in zone 0 (n = 17), 1 (n = 17), or 2 (n = 59) in 42% of patients. Technical success rate was 96.4%. Overall 30-day mortality was 11.7% (elective aneurysm, 11.6%; emergent aneurysm, 34.3%; acute type B dissection, 14.8%; chronic dissection, 4.2%; septic, 8.3%; and traumatic, 1.7%). Major adverse events included stroke in 4.5%, spinal cord ischemia in 1.8%, and retrograde aortic dissection in 2.7%. Mean follow-up was 43.4 ± 38 months. Estimated aortic complications-free survivals at 12, 36, 60, and 120 months were (% ± standard error) 73% ± 3%, 64% ± 4%, 62% ± 4% and 57% ± 5%, respectively. Multivariate analysis showed that patients treated for a chronic aortic dissection had a significant risk of late reintervention (P = .001) CONCLUSIONS: Because of its simplicity and low morbimortality rate, TEVAR has become the first-line approach for thoracic aortic diseases. Mortality outcomes are related to aortic pathology, emergent status, and proximal landing zone. To improve long-term results, rigorous patient selection and follow-up, development of referral centers, and technologic evolution of materials have to be reached.

摘要

目的

胸主动脉腔内修复术(TEVAR)存在特定并发症且缺乏长期数据。本研究旨在评估我们的长期TEVAR结果。

方法

这是一项对1998年至2013年期间接受TEVAR的223例患者的单中心回顾性研究。适应证包括动脉瘤(45%)、创伤性(26%)、夹层(23%)和感染性(6%)。

结果

患者的平均年龄为62.7±17.9岁,其中84%的患者美国麻醉医师协会评分≥3,42%的患者发生主动脉破裂。42%的患者在0区(n = 17)、1区(n = 17)或2区(n = 59)进行了TEVAR。技术成功率为96.4%。总体30天死亡率为11.7%(择期动脉瘤,11.6%;急诊动脉瘤,34.3%;急性B型夹层,14.8%;慢性夹层,4.2%;感染性,8.3%;创伤性,1.7%)。主要不良事件包括中风4.5%、脊髓缺血1.8%和逆行性主动脉夹层2.7%。平均随访时间为43.4±38个月。12、36、60和120个月时估计的无主动脉并发症生存率(%±标准误差)分别为73%±3%、64%±4%、62%±4%和57%±5%。多变量分析显示,接受慢性主动脉夹层治疗的患者有晚期再次干预的显著风险(P = 0.001)结论:由于其操作简单且病死亡率低,TEVAR已成为胸主动脉疾病的一线治疗方法。死亡率结果与主动脉病变、急诊状态和近端着陆区有关。为了改善长期结果,必须进行严格的患者选择和随访、建立转诊中心以及材料的技术改进。

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