来自黎巴嫩的携带blaOXA - 48的解鸟氨酸拉乌尔菌临床分离株的全基因组序列
Whole-Genome Sequence of a blaOXA-48-Harboring Raoultella ornithinolytica Clinical Isolate from Lebanon.
作者信息
Al-Bayssari Charbel, Olaitan Abiola Olumuyiwa, Leangapichart Thongpan, Okdah Liliane, Dabboussi Fouad, Hamze Monzer, Rolain Jean-Marc
机构信息
Laboratoire Microbiologie Santé et Environnement, Centre AZM pour la Recherche en Biotechnologie et ses Applications, Ecole Doctorale de Sciences et de Technologie, Université Libanaise, Tripoli, Lebanon Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
Aix-Marseille Université, URMITE UM 63, CNRS 7278, IRD 198, INSERM U1905, Facultés de Médecine et de Pharmacie, Marseille, France.
出版信息
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2548-50. doi: 10.1128/AAC.02773-15. Print 2016 Apr.
Abstract
We analyzed the whole-genome sequence of ablaOXA-48-harboringRaoultella ornithinolyticaclinical isolate from a patient in Lebanon. The size of theRaoultella ornithinolyticaCMUL058 genome was 5,622,862 bp, with a G+C content of 55.7%. We deciphered all the molecular mechanisms of antibiotic resistance, and we compared our genome to other availableR. ornithinolyticagenomes in GenBank. The resistome consisted of 9 antibiotic resistance genes, including a plasmidicblaOXA-48gene whose genetic organization is also described.
摘要
我们分析了从黎巴嫩一名患者身上分离出的携带blaOXA - 48的解鸟氨酸拉乌尔菌临床分离株的全基因组序列。解鸟氨酸拉乌尔菌CMUL058基因组大小为5,622,862 bp，G+C含量为55.7%。我们解析了所有抗生素耐药的分子机制，并将我们的基因组与GenBank中其他可用的解鸟氨酸拉乌尔菌基因组进行了比较。耐药基因组由9个抗生素耐药基因组成，包括一个质粒blaOXA - 48基因，其基因结构也有描述。
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