Chow Seong H, Deo Pankaj, Naderer Thomas
Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.
Cell Microbiol. 2016 Apr;18(4):466-74. doi: 10.1111/cmi.12573. Epub 2016 Feb 22.
Macrophages can respond to microbial infections with programmed cell death. The major cell death pathways of apoptosis, pyroptosis and necroptosis are tightly regulated to ensure adequate immune reactions to virulent and persistent invaders. Macrophage death eliminates the replicative niche of intracellular pathogens and induces immune attack. Not surprisingly, successful pathogens have evolved strategies to modulate macrophage cell death pathways to enable microbial survival and replication. Uncontrolled macrophage death can also lead to tissue damage, which may augment bacterial dissemination and pathology. In this review, we highlight how pathogens hijack macrophage cell death signals to promote microbial survival and immune evasion.
巨噬细胞可通过程序性细胞死亡对微生物感染作出反应。凋亡、焦亡和坏死性凋亡等主要细胞死亡途径受到严格调控，以确保对毒性强且持续存在的病原体产生充分的免疫反应。巨噬细胞死亡消除了细胞内病原体的复制微环境并引发免疫攻击。不出所料，成功的病原体已经进化出调节巨噬细胞死亡途径的策略，以实现微生物的存活和复制。不受控制的巨噬细胞死亡也会导致组织损伤，这可能会加剧细菌传播和病理变化。在本综述中，我们重点介绍病原体如何劫持巨噬细胞死亡信号以促进微生物存活和免疫逃避。
