为种系提供营养。
Feeding the germline.
作者信息
Shi Cheng, Murphy Coleen T
机构信息
Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
出版信息
Genes Dev. 2016 Feb 1;30(3):249-50. doi: 10.1101/gad.276980.115.
Abstract
Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307-320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
摘要
在发育中的生殖细胞系中复制DNA需要核苷酸。在此，Chi及其同事（第307 - 320页）利用秀丽隐杆线虫鉴定出了一种依赖GLP - 1的检查点，该检查点可感知食物（细菌）提供的核苷酸水平，在核苷酸供应不足时会阻止生殖发育。
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