Mallick Debkrishna, Thapa Rajoo, Biswas Biswajit
Department of Paediatric Medicine, HEEM, Boston, UK.
Department of Pediatrics, Golisano Children's Hospital, Syracuse, New York, USA.
BMJ Case Rep. 2016 Feb 1;2016:bcr2015212714. doi: 10.1136/bcr-2015-212714.
Acute leukaemias occur as the result of clonal expansion subsequent to transformation and arrest at a normal differentiation stage of haematopoietic precursors, which commit to a single lineage, such as myeloid or B-lymphoid or T-lymphoid cells. Biphenotypic acute leukaemia (BAL) constitutes a biologically different group of leukaemia arising from a precursor stem cell and co-expressing more than one lineage specific marker. The present report describes a child with unusual co-occurrence of biphenotypic (B-precursor cell and Myeloid) acute leukaemia, haemoglobin E trait and glucose 6-phosphate dehydrogenase (G6-PD) deficiency. To the best of our knowledge, this constellation of haematological conditions in a single child has never been described before.
急性白血病是造血前体细胞在正常分化阶段发生转化并停滞，随后进行克隆性扩增的结果，这些前体细胞会分化为单一谱系，如髓系、B淋巴细胞系或T淋巴细胞系细胞。双表型急性白血病（BAL）是一组生物学特性不同的白血病，起源于前体干细胞，同时表达一种以上谱系特异性标志物。本报告描述了一名儿童，其同时患有罕见的双表型（B前体细胞和髓系）急性白血病、血红蛋白E性状和葡萄糖6磷酸脱氢酶（G6-PD）缺乏症。据我们所知，单个儿童同时出现这一系列血液学病症此前从未有过报道。
