Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Kellogg College, University of Oxford, Banbury Road, Oxford, OX2 6PN, UK.
Adv Mater. 2016 Apr 13;28(14):2699-708. doi: 10.1002/adma.201506232. Epub 2016 Feb 2.
The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.
本文报道了使用功能性纳米金刚石（fND）递呈 CpG 寡核苷酸（ODN）以实现持续免疫刺激的方法。实验结果表明，该免疫刺激剂的单一疗法可显著抑制两种小鼠肿瘤模型中的肿瘤生长。这种基于 fND 的纳米制剂为免疫疗法以及各种治疗性核酸的临床应用开辟了新的机会。
