Elkina S I, Beĭlina V B, Ispolatovskaia E O, Kalina N G, Novikova A V
Zh Mikrobiol Epidemiol Immunobiol. 1989 Jul(7):74-8.
The results obtained in the study of the dynamics of systemic and local immunity characteristics in children with prolonged and chronic dysentery under the influence of vaccinal therapy are presented. The vaccine, containing soluble antigenic complexes isolated from Shigella sonnei cells by disintegration with hydroxylamine, was introduced intrarectally in doses of 2-4 mg. The course of treatment consisted of 5-6 administrations. The vaccinal therapy resulted in an increase in the level of immunoglobulins and the titer of specific antibodies, particularly IgA, in sera and fecal filtrates. These data coincided with an increase in the number of IgA-producing cells in bioptic samples of the mucous membrane of the large intestine. The vaccinal therapy contributed to the cessation of the release of bacteria in 82.5% of the patients.
本文呈现了在疫苗治疗影响下，对患有迁延性和慢性痢疾儿童的全身及局部免疫特性动态研究所得的结果。该疫苗含有通过用羟胺分解从宋内志贺氏菌细胞中分离出的可溶性抗原复合物，以2 - 4毫克的剂量经直肠给药。治疗疗程包括5 - 6次给药。疫苗治疗导致血清和粪便滤液中免疫球蛋白水平及特异性抗体效价升高，尤其是IgA。这些数据与大肠黏膜活检样本中产生IgA的细胞数量增加相一致。疫苗治疗促使82.5%的患者停止排菌。
