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来自海洋海绵的新的具有细胞毒性的环状过氧酸。

New cytotoxic cyclic peroxide acids from sp. marine sponge.

作者信息

Hoye Thomas R, Alarif Walied M, Basaif Salim S, Abo-Elkarm Mohamed, Hamann Mark T, Wahba Amir E, Ayyad Seif-Eldin N

机构信息

Chemistry Department, Univeristy of Minnesota, Minneapolis, Minnesota 55455, USA.

Marine Chemistry Department, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah 21589, Saudi Arabia.

出版信息

ARKIVOC. 2015;2015(5):164-175. doi: 10.3998/ark.5550190.p008.948. Epub 2015 Apr 5.

DOI:10.3998/ark.5550190.p008.948
PMID:26835518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4732738/
Abstract

Bioassay-guided fractionation of the extract of Jamaican marine sponge sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (), known plakortides (), known bicyclic lactone () and new cyclic peroxide acids (). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

摘要

对牙买加海洋海绵提取物进行生物测定导向的分级分离，随后进行制备型薄层色谱和高效液相色谱，得到了几种已知的甲酯环过氧化物（）、已知的 plakortides（）、已知的双环内酯（）和新的环过氧化物酸（）。通过对其光谱数据的广泛解读阐明了化学结构。这些天然产物对几种癌细胞系显示出显著的体外细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f74/4732738/90dba7517c25/nihms-752764-f0001.jpg

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本文引用的文献

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J Nat Prod. 1996 Mar;59(3):219-23. doi: 10.1021/np960087v.
2
Antifungal peroxyketal acids from an Okinawan marine sponge of Plakortis sp.来自冲绳海洋海绵Plakortis sp.的抗真菌过氧缩酮酸
Chem Pharm Bull (Tokyo). 1993 Jul;41(7):1324-6. doi: 10.1248/cpb.41.1324.
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Sensitivity of cultured human and mouse fibroblasts to trichothecenes.培养的人及小鼠成纤维细胞对单端孢霉烯族毒素的敏感性。
J Assoc Off Anal Chem. 1984 May-Jun;67(3):607-10.

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