神经性厌食症康复女性的预测误差与体感岛叶激活
Prediction error and somatosensory insula activation in women recovered from anorexia nervosa.
作者信息
Frank Guido K W, Collier Shaleise, Shott Megan E, O'Reilly Randall C
机构信息
From the Department of Psychiatry, University of Colorado, Denver, Aurora, CO, USA (Frank, Collier, Shott); the Department of Neuroscience, University of Colorado Denver; Anschutz Medical Campus, Aurora (Frank); and the Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA (O'Reilly).
出版信息
J Psychiatry Neurosci. 2016 Aug;41(5):304-11. doi: 10.1503/jpn.150103.
BACKGROUND
Previous research in patients with anorexia nervosa showed heightened brain response during a taste reward conditioning task and heightened sensitivity to rewarding and punishing stimuli. Here we tested the hypothesis that individuals recovered from anorexia nervosa would also experience greater brain activation during this task as well as higher sensitivity to salient stimuli than controls.
METHODS
Women recovered from restricting-type anorexia nervosa and healthy control women underwent fMRI during application of a prediction error taste reward learning paradigm.
RESULTS
Twenty-four women recovered from anorexia nervosa (mean age 30.3 ± 8.1 yr) and 24 control women (mean age 27.4 ± 6.3 yr) took part in this study. The recovered anorexia nervosa group showed greater left posterior insula activation for the prediction error model analysis than the control group (family-wise error- and small volume-corrected p < 0.05). A group × condition analysis found greater posterior insula response in women recovered from anorexia nervosa than controls for unexpected stimulus omission, but not for unexpected receipt. Sensitivity to punishment was elevated in women recovered from anorexia nervosa.
LIMITATIONS
This was a cross-sectional study, and the sample size was modest.
CONCLUSION
Anorexia nervosa after recovery is associated with heightened prediction error-related brain response in the posterior insula as well as greater response to unexpected reward stimulus omission. This finding, together with behaviourally increased sensitivity to punishment, could indicate that individuals recovered from anorexia nervosa are particularly responsive to punishment. The posterior insula processes somatosensory stimuli, including unexpected bodily states, and greater response could indicate altered perception or integration of unexpected or maybe unwanted bodily feelings. Whether those findings develop during the ill state or whether they are biological traits requires further study.
背景
先前针对神经性厌食症患者的研究表明，在味觉奖励条件任务期间大脑反应增强，并且对奖励和惩罚刺激的敏感性增强。在此，我们检验了这样一个假设，即从神经性厌食症中康复的个体在该任务期间也会比对照组经历更大的大脑激活以及对显著刺激更高的敏感性。
方法
从限制型神经性厌食症中康复的女性和健康对照女性在应用预测误差味觉奖励学习范式期间接受了功能磁共振成像（fMRI）检查。
结果
24名从神经性厌食症中康复的女性（平均年龄30.3±8.1岁）和24名对照女性（平均年龄27.4±6.3岁）参与了本研究。在预测误差模型分析中，康复的神经性厌食症组比对照组显示出更大的左侧岛叶后部激活（家族性错误率和小体积校正p<0.05）。一项组×条件分析发现，从神经性厌食症中康复的女性比对照组在意外刺激遗漏时岛叶后部反应更大，但在意外接收时并非如此。从神经性厌食症中康复的女性对惩罚的敏感性升高。
局限性
这是一项横断面研究，样本量适中。
结论
康复后的神经性厌食症与岛叶后部与预测误差相关的大脑反应增强以及对意外奖励刺激遗漏的更大反应有关。这一发现，连同行为上对惩罚的敏感性增加，可能表明从神经性厌食症中康复的个体对惩罚特别敏感。岛叶后部处理体感刺激，包括意外的身体状态，更大的反应可能表明对意外或可能不需要的身体感觉的感知或整合发生了改变。这些发现是在患病状态期间发展而来的，还是生物学特征，需要进一步研究。
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