Katzeff H L, Danforth E
Department of Medicine, University of Vermont College of Medicine, Burlington.
Am J Clin Nutr. 1989 Nov;50(5):915-21. doi: 10.1093/ajcn/50.5.915.
Short-term mixed calorie overfeeding increases basal energy expenditure in man but its effects on the thermic effect of a meal (TEM) are unclear. The thermogenic and hormonal responses to an 800-kcal liquid mixed meal were measured in six lean and six obese subjects during weight maintenance, during 18 d of overfeeding 1000 kcal/d, and during 18 d of a 589 kcal/d diet (obese subjects only). There was no change in the TEM in lean subjects between weight maintenance and overfeeding. In the obese group the TEM was lower during both overfeeding (p less than 0.05) and underfeeding (p less than 0.05) compared with weight maintenance. Overfeeding increased rates of net postprandial glucose oxidation and decreased lipid oxidation in the lean subjects only. Alterations in glucose oxidation rates and the insulin response to meals may contribute to an impaired TEM in human obesity during overnutrition.
短期混合热量过度喂养可增加人体的基础能量消耗，但其对进餐热效应（TEM）的影响尚不清楚。在体重维持期、每天过量喂养1000千卡的18天期间以及每天589千卡饮食期（仅针对肥胖受试者），测量了6名瘦人和6名肥胖受试者对一顿800千卡液体混合餐的产热和激素反应。在体重维持期和过度喂养期，瘦人受试者的TEM没有变化。与体重维持期相比，肥胖组在过度喂养期（p<0.05）和进食不足期（p<0.05）的TEM均较低。仅在瘦人受试者中，过度喂养增加了餐后净葡萄糖氧化率并降低了脂质氧化率。葡萄糖氧化率的改变以及对餐食的胰岛素反应可能导致营养过剩期间人类肥胖患者的TEM受损。
